Intraoperative and immediate postoperative transfusion: Clinical-hematological profile of transfunded patients in a university hospital.

INTRODUCTION: The transfusion practice by surgery blood reserve, varied among services, must be performed through the rational and restrictive use of blood components because it is a scarce and expensive resource for health care services. OBJECTIVE: Analyze the use of blood products for surgery blood reserve by means of the study of the clinical-hematological profile of patients submitted to intraoperative and immediate postoperative transfusions. METHODS: This was an observational, cross-sectional, and retrospective study, conducted by collecting biological, operational, and laboratory variables, involving 680 patients at a university hospital who had elective surgery with surgery blood reserve request sent during the period from October 2021 to October 2022. RESULTS: The overall transfusion rate was 25.44%, and the mean preoperative hemoglobin level of transfused patients was 9.74 ± 2.50 g/dL, with the mean number of transfusions packed red blood cell units was 1.58 ± 0.77. Patients with higher preoperative hemoglobin levels were less likely to have transfusion (p < 0.001) and patients who had surgical oncologic were more likely to require transfusion (p = 0.048). The transfusion rate of packed red blood cells and platelets concentrates, compared to what was requested, was 15.86% and 5.82%. CONCLUSION: There is a tendency of transfusions to follow restrictive models, with higher transfusion probability in surgical oncologic. Furthermore, there should be more a conscise use of the surgery blood reserves request.

The impact of pharmacological and non-pharmacological interventions on physical health outcomes in people with mood disorders across the lifespan: An umbrella review of the evidence from randomised controlled trials.

OBJECTIVE: People with mood disorders have increased risk of comorbid medical diseases versus the general population. It is paramount to identify interventions to improve physical health in this population. METHODS: Umbrella review of meta-analyses of randomised controlled trials (RCTs) on pharmacological/non-pharmacological interventions for physical health outcomes/intolerability-related discontinuation in mood disorders (any age). RESULTS: Ninety-seven meta-analyses were included. Among youths, against placebo, in depression, antidepressants/antipsychotics had higher discontinuation rates; in bipolar depression, olanzapine+fluoxetine worsened total cholesterol (TC)/triglycerides/weight gain (WG) (large ES). In adults with bipolar disorder, olanzapine worsened HbA1c/TC/WG (moderate/large ES); asenapine increased fasting glucose (small ES); quetiapine/cariprazine/risperidone induced WG (small/moderate ES). In bipolar depression, lurasidone was metabolically neutral. In depression, psychological interventions improved physical health-related quality of life (PHQoL) (small ES), fasting glucose/HbA1c (medium/large ES); SSRIs improved fasting glucose/HbA1c, readmission for coronary disease, pain (small ES); quetiapine/aripiprazole/olanzapine induced WG (small to large ES). Exercise improved cardiorespiratory fitness (moderate ES). In the elderly, fluoxetine yielded more detrimental cardiovascular effects than sertraline/escitalopram (large ES); antidepressants were neutral on exercise tolerance and PHQoL. In mixed age groups, in bipolar disorder aripiprazole was metabolically neutral; in depression, SSRIs lowered blood pressure versus placebo and serotonin-noradrenaline reuptake inhibitors (small ES); brexpiprazole augmentation caused WG and was less tolerated (small ES); exercise improved PHQoL (moderate ES). CONCLUSIONS: Some interventions (psychological therapies, exercise and SSRIs) improve certain physical health outcomes in mood disorders, few are neutral, but various pharmacological interventions are associated with negative effects. Evidence from this umbrella review has limitations, should consider evidence from other disorders and should be integrated with recent evidence from individual RCTs, and observational evidence. Effective treatments with either beneficial or physically neutral profiles should be prioritized.

[Trends in suicide rates in Brazil from 2011 to 2020: special focus on the COVID-19 pandemicTendencia de las tasas de suicidio en Brasil, 2011-2020, con especial atención a la pandemia de COVID-19]. / Tendência de suicídio no Brasil de 2011 a 2020: foco especial na pandemia de covid-19.

Objective: To describe the trends in suicide rates in Brazil from 2011 to 2020 and determine whether these rates are associated with COVID-19 pandemic-related variables. Method: This ecological time series study analyzed mortality from suicide with a focus on 2020, the first year of the COVID-19 pandemic. The suicide mortality rate per 100,000 population was the primary outcome. The trends in suicide rates were estimated using generalized Prais-Winsten regression. An autoregressive integrated moving average (ARIMA) model was used to predict suicide rates in 2020. The association between suicide rates and death rates from COVID-19, unemployment, receiving emergency financial aid, and rates of social distancing was investigated. Results: From 2011 to 2020, 115 469 deaths by suicide were recorded in Brazil (60.5 deaths/100 000 population). The suicide rate in 2020 was 6.68/100 000 population. An increasing trend in suicide rates was observed from 2011 to 2020 in both sexes, with annual percent change of 0.23 (95%CI: 0.141; 0.322) in women; and 1.19 (95%CI: 0.714; 1.810) in men. Mortality by suicide increased in all regions, with the highest increase recorded in the South. There was no evidence of increase in deaths by suicide in relation to the expected number during the first year of the COVID-19 pandemic. Conclusions: Suicide rates increased for both sexes and in all Brazilian states. In the first pandemic year, the number of deaths by suicide did not increase in relation to the expected number, with a stability trend during the months of 2020.

Objetivo: Describir la tendencia de las tasas de suicidio en Brasil durante el período 2011-2020 y determinar su asociación con las variables relacionadas con la pandemia de COVID-19. Métodos: En este estudio ecológico y de serie temporal se analizó la mortalidad por suicidio, en particular en el 2020, el primer año de la pandemia de COVID-19. El resultado principal fue la tasa de mortalidad por suicidio por 100.000 habitantes. La tendencia de las tasas de suicidio se calculó mediante una regresión generalizada de Prais-Winsten y para el pronóstico correspondiente al 2020 se utilizó el modelo autorregresivo integrado de promedio móvil (ARIMA). Se investigó la asociación entre las tasas de suicidio y las tasas de muerte por COVID-19, el desempleo, el recibir ayuda económica de emergencia y las tasas de distanciamiento social. Resultados: En el período 2011-2020, se registraron 115.469 suicidios en Brasil (60,5 muertes por 100.000 habitantes). La tasa de suicidio en el 2020 fue de 6,68 por 100.000 habitantes. Se observó un aumento en la tendencia de las tasas de suicidio en las personas de ambos sexos en el período 2011-2020, con una variación anual porcentual de 0,23 (IC 95%: 0,141; 0,322) en las mujeres y de 1,19 (IC 95%: 0,714; 1,810) en los hombres. La mortalidad por suicidio aumentó en todas las regiones y la mayor tasa se registró en la región sur. No hubo evidencia de una intensificación del número de casos de suicidio con respecto a lo previsto en el primer año de la pandemia de COVID-19. Conclusiones: Las tasas de suicidio de personas de ambos sexos aumentaron en todos los estados de Brasil. En el primer año de la pandemia no se observó ningún aumento en comparación con la tasa prevista y la tendencia se mantuvo estable durante el transcurso del 2020.

Tendência de suicídio no Brasil de 2011 a 2020: foco especial na pandemia de covid-19

[RESUMO]. Objetivo. Descrever a tendência das taxas de suicídio no Brasil de 2011 a 2020 e determinar a associação dessas taxas com variáveis relacionadas à pandemia de covid-19. Métodos. Este estudo ecológico de série temporal analisou a mortalidade por suicídio com destaque para 2020, primeiro ano da pandemia. A taxa de mortalidade por suicídio/100 mil indivíduos foi o desfecho primá- rio. A tendência das taxas de suicídio foi calculada por regressão generalizada de Prais-Winsten e a previsão das taxas de suicídio em 2020 utilizou o modelo Autoregressive Integrated Moving Average (ARIMA). Inves- tigou-se a associação entre taxas de suicídio e taxas de mortes por covid-19, desemprego, recebimento de auxílio financeiro emergencial e taxas de distanciamento social. Resultados. De 2011 a 2020, foram registrados 115 469 suicídios no Brasil (60,5 óbitos/100 mil habitantes). A taxa de suicídio em 2020 foi de 6,68/100 mil habitantes. A tendência das taxas de suicídios de 2011 a 2020 apresentou alta em ambos os sexos, com variação percentual anual de 0,23 (IC95%: 0,141; 0,322) em mulheres; e de 1,19 (IC95%: 0,714; 1,810) em homens. A mortalidade por suicídio cresceu em todas as regi- ões, com maior alta no Sul. Não houve evidências de recrudescimento dos suicídios em relação ao número esperado durante o primeiro ano da pandemia de covid-19. Conclusões. As taxas de suicídios cresceram em ambos os sexos e em todos os estados brasileiros. No primeiro ano da pandemia não houve aumento de suicídios em relação ao número esperado, com tendência estável durante os meses de 2020.

[ABSTRACT]. Objective. To describe the trends in suicide rates in Brazil from 2011 to 2020 and determine whether these rates are associated with COVID-19 pandemic-related variables. Method. This ecological time series study analyzed mortality from suicide with a focus on 2020, the first year of the COVID-19 pandemic. The suicide mortality rate per 100,000 population was the primary outcome. The trends in suicide rates were estimated using generalized Prais-Winsten regression. An autoregressive inte- grated moving average (ARIMA) model was used to predict suicide rates in 2020. The association between suicide rates and death rates from COVID-19, unemployment, receiving emergency financial aid, and rates of social distancing was investigated. Results. From 2011 to 2020, 115 469 deaths by suicide were recorded in Brazil (60.5 deaths/100 000 popula- tion). The suicide rate in 2020 was 6.68/100 000 population. An increasing trend in suicide rates was observed from 2011 to 2020 in both sexes, with annual percent change of 0.23 (95%CI: 0.141; 0.322) in women; and 1.19 (95%CI: 0.714; 1.810) in men. Mortality by suicide increased in all regions, with the highest increase recorded in the South. There was no evidence of increase in deaths by suicide in relation to the expected number during the first year of the COVID-19 pandemic. Conclusions. Suicide rates increased for both sexes and in all Brazilian states. In the first pandemic year, the number of deaths by suicide did not increase in relation to the expected number, with a stability trend during the months of 2020.

[RESUMEN]. Objetivo. Describir la tendencia de las tasas de suicidio en Brasil durante el período 2011-2020 y determinar su asociación con las variables relacionadas con la pandemia de COVID-19. Métodos. En este estudio ecológico y de serie temporal se analizó la mortalidad por suicidio, en particular en el 2020, el primer año de la pandemia de COVID-19. El resultado principal fue la tasa de mortalidad por suicidio por 100.000 habitantes. La tendencia de las tasas de suicidio se calculó mediante una regresión generalizada de Prais-Winsten y para el pronóstico correspondiente al 2020 se utilizó el modelo autorregre- sivo integrado de promedio móvil (ARIMA). Se investigó la asociación entre las tasas de suicidio y las tasas de muerte por COVID-19, el desempleo, el recibir ayuda económica de emergencia y las tasas de distancia- miento social. Resultados. En el período 2011-2020, se registraron 115.469 suicidios en Brasil (60,5 muertes por 100.000 habitantes). La tasa de suicidio en el 2020 fue de 6,68 por 100.000 habitantes. Se observó un aumento en la tendencia de las tasas de suicidio en las personas de ambos sexos en el período 2011-2020, con una varia- ción anual porcentual de 0,23 (IC 95%: 0,141; 0,322) en las mujeres y de 1,19 (IC 95%: 0,714; 1,810) en los hombres. La mortalidad por suicidio aumentó en todas las regiones y la mayor tasa se registró en la región sur. No hubo evidencia de una intensificación del número de casos de suicidio con respecto a lo previsto en el primer año de la pandemia de COVID-19. Conclusiones. Las tasas de suicidio de personas de ambos sexos aumentaron en todos los estados de Bra- sil. En el primer año de la pandemia no se observó ningún aumento en comparación con la tasa prevista y la tendencia se mantuvo estable durante el transcurso del 2020.

Determinants of Cognitive Performance in Children and Adolescents: A Populational Longitudinal Study.

We evaluated the determinants of cognitive performance in children and adolescents. This is a longitudinal study, secondary analysis of the Physical Activity and Nutrition in Children (PANIC) study. We assessed 502 children (51.6% girls) at middle childhood (range: 6.6 to 9.0 years), at late childhood, 437 children (51.0% girls, range: 8.8 to 11.2 years), and in 277 adolescents (54.5% girls, range: 15.0 to 17.4 years). Raven's progressive matrices tests estimated the participants' cognitive performance (outcome variable) at all time points. In total, we evaluated 29 factors from various dimensions (prenatal, neonatal, child fitness, lifestyle and anthropometrics). None of the neonatal and anthropometric parameters were associated with cognitive performance. Preeclampsia (prenatal) and listening to music, writing, arts and craft and watching TV (lifestyle) were negatively associated with cognitive performance. Shuttle run and box and block tests (fitness), and playing music, reading and time at the computer (lifestyle) were positive determinants of cognitive performance in children and adolescents. Fitness and lifestyle factors during childhood and adolescence diminished the importance of prenatal factors on cognitive performance and lifestyle factors were especially relevant in regard to cognitive performance. Reading was positively associated with cognitive performance, regardless of age and time dedicated, and should be promoted.

Acculturation and 4-year caries increment among children of foreign-born mothers in Sweden: a register-based cohort study.

BACKGROUND: To study the association of maternal age upon arrival and length of residence in Sweden with the 4-year caries increment in their children between ages 3 and 7 years in relation to the human development index (HDI) of the maternal country of origin. METHOD: This registry-based cohort study included all children born in 2000-2003 who resided in Stockholm County, Sweden, at age 3 years and who were followed up at age 7 (n = 63,931). Negative binomial regressions were used to analyze different models adjusted for sociodemographic factors. RESULTS: Children of foreign-born mothers, regardless of the HDI of the maternal country of origin, had a higher risk of caries increment between ages 3 and 7 years than children of Swedish-born mothers. Furthermore, children of mothers who had arrived from a low or medium HDI country had a lower caries increment if their mothers arrived before age 7 compared with after age 7. Nearly half (44%) of the children whose mothers arrived in Sweden at age ≥ 20 years from a low HDI country had a caries increment compared to 22% of the children whose mothers had arrived in Sweden before 7 years of age. Furthermore, children whose mothers were born in a low HDI country and had resided in Sweden ≤ 19 years had approximately 1.5 times higher risk of caries increment compared to children of mothers who had resided in Sweden for more than 20 years. CONCLUSIONS: Caries increment in the children of foreign-born mothers was associated with the age of their mother when she arrived in Sweden and was lower when the mother had arrived before age 7 years. This indicates an intergenerational effect that carries over to the children and is greater the longer the mother has participated in Swedish dental healthcare.

Participação nas aulas de Educação Física em Pernambuco: uma análise de tendência temporal / Participation in Physical Education classes in Pernambuco: a temporal trend analysis

O objetivo do estudo foi analisar a tendência temporal e fatores associados à participação nas aulas de educação física de estudantes de Pernambuco. Estudo de tendência temporal composto por três levantamentos de abrangência estadual. Foram entrevistados 4.207 estudantes em 2006, 6.264 em 2011 e 6.002 em 2016, por meio do questionário "Global School-based Student Health Survey" (GSHS). O desfecho foi a participação nas aulas de Educação Física e as exposições foram as informações sociodemográficas. A análise bivariada foi realizada mediante teste Qui-quadrado e as análises multivariadas por regressão logística binária. Observou-se um aumento na prevalência de participação nas aulas de Educação Física (2006: 35%, 2011: 74% e 2016: 81,2%) destacando o aumento significativo no sexo masculino Δ% (2006-2016) = 123,5%. Ser do sexo masculino, estudar no período integral e ser filho de mães que estudaram, independente do tempo de estudo foi associado a maior participação nas aulas de educação física, assim como residir nas regiões do Agreste, Sertão e Sertão do São Francisco. Apesar do aumento na participação nas aulas de Educação Física em Pernambuco, a garantia deste componente curricular deve ser fortalecida, levando em consideração os grupos de risco para que aumente a participação nas aulas desses grupos

The aim of the study was to analyze the temporal trend and factors associated with participation in physical education classes in Pernambuco. The temporal trend study was composed of three surveys. A total of 4,207 students were interviewed in 2006, 6,264 in 2011 and 6,002 in 2016, using the "Global School-based Stu-dent Health Survey" (GSHS) questionnaire. The outcome was participation in Physical Education classes and the independent variables were sociodemographic information. The bivariate analysis was performed using the chi-square test and the multivariate analysis using binary logistic regression. There was an increase in the prevalence of participation in Physical Education classes (2006: 35%, 2011: 74% and 2016: 81.2%), highlighting the significant increase in males Δ% (2006-2016) = 123.5%. Male, studying full-time and being the son of mothers who studied was associated with greater participation in physical education classes, as well as living in the regions of Agreste, Sertão and Sertão do São Francisco. Despite the increase in par-ticipation in Physical Education classes in Pernambuco, the guarantee of this curricular component must be strengthened, considering risk groups in order to increase participation in classes for these groups

Universal school-based intervention targeting depressive symptoms in adolescents: A cluster randomized trial.

We investigated the effects of three different interventions on depressive symptoms in adolescents. As a secondary aim, we explored the mediating role of social isolation, anxiety, sleep quality, and cognitive function of the intervention effect on depressive symptoms. We conducted a cluster randomized controlled trial, in which schools were randomly assigned to 1. Doubling physical education (PE) classes (3:20 h of PE/week); 2. Workshop with the PE teachers; 3. Workshop with the PE teachers + Doubling PE classes; and 4. Control group (1:40 h of PE/week). In total, 1279 adolescents were included, 56.4% females. Doubling PE classes and the workshop with the PE teachers + Doubling PE classes groups did not affect depressive symptoms (-0.947, 95% CI -3.176 to 1.281; and, 0.726, 95% CI -1.558 to 3.009, respectively). The workshop with the PE teachers decreased adolescents' depressive symptoms (-2.495, 95% CI -4.668 to -0.323), social isolation (-4.759, 95% CI -9.025 to -0.493), and poor sleep quality (-0.560, 95% CI -1.108 to -0.012) compared with the control group. Social isolation mediated 32% of the workshop effect on depressive symptoms. The workshop with the PE teachers and the workshop with the PE teachers + Doubling PE classes groups lowered in 93% and in 54% the risk of the adolescents in developing high depressive symptomatology compared with the control group, respectively. A workshop updating PE teachers on pedagogical and health-related topics decreased depressive symptoms in adolescents. Moreover, improvements in the adolescents' social isolation mediated the effect of PE teachers' workshop intervention on the depressive symptoms in adolescents.

The Role of Adiposity in the Association Between Physical Activity and Blood Pressure in Children.

Purpose: To analyze whether body adiposity mediates and/or moderates the association between time in moderate-to-vigorous physical activities (MVPA) and blood pressure in children. Methods: This was a cross-sectional study of 577 children aged 5 to 7 years old. MVPA was measured by accelerometry. Body mass index (BMI), waist circumference (WC), and the sum of tricipital and subscapular skinfolds (skinfolds) assessed children's body adiposity. Systolic (SBP) and diastolic blood pressure (DBP) were used as the dependent variables. Results: In the primary analysis adjusting for BMI or skinfolds measures, additional time in MVPA was associated with higher SBP. On the other hand, further analyses showed that children in the largest BMI tertile (ßSBP:0.18; 95%CI: 0.12-0.24; ßDBP:0.11; 95%CI: 0.05-0.17), waist circumference (ßSBP:0.16; CI: 0.09-0.22; ßDBP:0.08; CI:0.02-0.14), or sum of skinfolds (ßSBP:0.18; CI: 0.11-0.24; ßDBP:0.09; CI: 0.03-0.16) presented a positive relationship between MVPA and blood pressure whereas no positive association was observed for children in the first and second adiposity tertiles. Adiposity also mediated the association between MVPA and blood pressure. A decrease of 0.03 mmHg in the systolic blood pressure was observed by decreasing the sum of skinfolds for each additional minute per day in MVPA. A decrease in diastolic blood pressure of 0.02 mmHg was observed for each additional minute per day in MVPA, which was related to a negative association between time in MVPA and waist circumference and sum of skinfolds. Conclusion: Not accounting for the potential moderation and mediation role of adiposity may lead to misinterpretations in the MVPA and blood pressure relationship.

Tendência de suicídio no Brasil de 2011 a 2020: foco especial na pandemia de covid-19 / Trends in suicide rates in Brazil from 2011 to 2020: special focus on the COVID-19 pandemic / Tendencia de las tasas de suicidio en Brasil, 2011-2020, con especial atención a la pandemia de COVID-19

RESUMO Objetivo. Descrever a tendência das taxas de suicídio no Brasil de 2011 a 2020 e determinar a associação dessas taxas com variáveis relacionadas à pandemia de covid-19. Métodos. Este estudo ecológico de série temporal analisou a mortalidade por suicídio com destaque para 2020, primeiro ano da pandemia. A taxa de mortalidade por suicídio/100 mil indivíduos foi o desfecho primário. A tendência das taxas de suicídio foi calculada por regressão generalizada de Prais-Winsten e a previsão das taxas de suicídio em 2020 utilizou o modelo Autoregressive Integrated Moving Average (ARIMA). Investigou-se a associação entre taxas de suicídio e taxas de mortes por covid-19, desemprego, recebimento de auxílio financeiro emergencial e taxas de distanciamento social. Resultados. De 2011 a 2020, foram registrados 115 469 suicídios no Brasil (60,5 óbitos/100 mil habitantes). A taxa de suicídio em 2020 foi de 6,68/100 mil habitantes. A tendência das taxas de suicídios de 2011 a 2020 apresentou alta em ambos os sexos, com variação percentual anual de 0,23 (IC95%: 0,141; 0,322) em mulheres; e de 1,19 (IC95%: 0,714; 1,810) em homens. A mortalidade por suicídio cresceu em todas as regiões, com maior alta no Sul. Não houve evidências de recrudescimento dos suicídios em relação ao número esperado durante o primeiro ano da pandemia de covid-19. Conclusões. As taxas de suicídios cresceram em ambos os sexos e em todos os estados brasileiros. No primeiro ano da pandemia não houve aumento de suicídios em relação ao número esperado, com tendência estável durante os meses de 2020.

ABSTRACT Objective. To describe the trends in suicide rates in Brazil from 2011 to 2020 and determine whether these rates are associated with COVID-19 pandemic-related variables. Method. This ecological time series study analyzed mortality from suicide with a focus on 2020, the first year of the COVID-19 pandemic. The suicide mortality rate per 100,000 population was the primary outcome. The trends in suicide rates were estimated using generalized Prais-Winsten regression. An autoregressive integrated moving average (ARIMA) model was used to predict suicide rates in 2020. The association between suicide rates and death rates from COVID-19, unemployment, receiving emergency financial aid, and rates of social distancing was investigated. Results. From 2011 to 2020, 115 469 deaths by suicide were recorded in Brazil (60.5 deaths/100 000 population). The suicide rate in 2020 was 6.68/100 000 population. An increasing trend in suicide rates was observed from 2011 to 2020 in both sexes, with annual percent change of 0.23 (95%CI: 0.141; 0.322) in women; and 1.19 (95%CI: 0.714; 1.810) in men. Mortality by suicide increased in all regions, with the highest increase recorded in the South. There was no evidence of increase in deaths by suicide in relation to the expected number during the first year of the COVID-19 pandemic. Conclusions. Suicide rates increased for both sexes and in all Brazilian states. In the first pandemic year, the number of deaths by suicide did not increase in relation to the expected number, with a stability trend during the months of 2020.

RESUMEN Objetivo. Describir la tendencia de las tasas de suicidio en Brasil durante el período 2011-2020 y determinar su asociación con las variables relacionadas con la pandemia de COVID-19. Métodos. En este estudio ecológico y de serie temporal se analizó la mortalidad por suicidio, en particular en el 2020, el primer año de la pandemia de COVID-19. El resultado principal fue la tasa de mortalidad por suicidio por 100.000 habitantes. La tendencia de las tasas de suicidio se calculó mediante una regresión generalizada de Prais-Winsten y para el pronóstico correspondiente al 2020 se utilizó el modelo autorregresivo integrado de promedio móvil (ARIMA). Se investigó la asociación entre las tasas de suicidio y las tasas de muerte por COVID-19, el desempleo, el recibir ayuda económica de emergencia y las tasas de distanciamiento social. Resultados. En el período 2011-2020, se registraron 115.469 suicidios en Brasil (60,5 muertes por 100.000 habitantes). La tasa de suicidio en el 2020 fue de 6,68 por 100.000 habitantes. Se observó un aumento en la tendencia de las tasas de suicidio en las personas de ambos sexos en el período 2011-2020, con una variación anual porcentual de 0,23 (IC 95%: 0,141; 0,322) en las mujeres y de 1,19 (IC 95%: 0,714; 1,810) en los hombres. La mortalidad por suicidio aumentó en todas las regiones y la mayor tasa se registró en la región sur. No hubo evidencia de una intensificación del número de casos de suicidio con respecto a lo previsto en el primer año de la pandemia de COVID-19. Conclusiones. Las tasas de suicidio de personas de ambos sexos aumentaron en todos los estados de Brasil. En el primer año de la pandemia no se observó ningún aumento en comparación con la tasa prevista y la tendencia se mantuvo estable durante el transcurso del 2020.

Constructs of poor sleep quality in adolescents: associated factors.

This study aims to evaluate factors associated with sleep quality (overall and by domains) in adolescents. A cross-sectional study. This study was conducted with 1,296 first-year high school students from public schools in the Northern Region of the State of Pernambuco, Brazil. Demographic, socioeconomic, and behavioral data were obtained with a questionnaire. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI) Body mass index (BMI) was calculated based on the ratio of weight and height squared. Multilevel linear and logistic regressions evaluated factors associated with sleep quality. We observed 53% of adolescents reported poor sleep quality. Adolescents at higher risk of clinical depression were 3.45 times more likely to have poor sleep quality (95%CI: 2.04; 5.81), and each additional unit in the social anxiety score presented 1.03 (95%CI: 1.01; 1.05) higher odds of adolescents having poor sleep quality. Adolescents with depressive symptoms had higher sleep latency, greater sleep disturbance, and greater daytime sleep dysfunction. Social anxiety was associated with sleep latency, sleep disturbance, and daytime sleep dysfunction. Higher risk of clinical depression was associated with all domains related to sleep quality. Negative health perception was associated with sleep disturbance, and physical inactivity was associated with daytime sleep dysfunction. Social anxiety and especially higher risk of clinical depression were determinants of poor sleep quality. Changes in sleep latency, sleep disturbance and daytime sleep dysfunction seems to be relevant to poor sleep quality.

Depressive symptoms in older adults: the role of physical activity and social support

Abstract Objective To evaluate the role of social support in the association between physical activity (PA) in its various domains and depressive symptoms in older adults. Methods This was a cross-sectional study involving 399 older adults seen at basic health units in the municipality of Recife, state of Pernambuco, northeastern Brazil. Linear regression was implemented using the forward method to assess the association between PA and its domains and depressive symptoms, as well as to test the possible moderating component of social support in this association. Results Of the total sample, 17.6% reported not practicing PA; 6.7% presented depressive symptoms, with a mean score of 1.59 points. A total of 18.6% of the older adults assessed reported not having social support. Older adults who did not practice total, transportation or domestic PA showed increased scores of depressive symptoms when compared to older adults who practiced PA in these domains. Older adults with social support also had fewer depressive symptoms. Practicing domestic, leisure and total PA, and/or having social support, decreased depressive symptoms in older adults. Having social support or practicing PA decreased depressive symptoms in older adults in a similar way. Conclusions Older adults with social support and who practiced PA, especially domestic and total PA, presented the lowest scores of depressive symptoms. The data showed the importance of providing elements to strengthen social support and PA practice in older adults living in poor communities as a strategy to prevent and reduce depressive symptoms.

Violence and psychosocial stress: A 10-year time trend analysis.

AIM: The aim of this study was to analyze the temporal trend of psychosocial stress and its association between exposure to violence in adolescents. METHODS: This is a cross-sectional study of temporal trends based on three school-based and statewide surveys with regular intervals of five years. The target population consisted of high school students from public schools. A total of 4,207 adolescents were evaluated in 2006, 6,264 in 2011, and 6,002 in 2016. The psychosocial stress indicator was the dependent study variable and was analyzed according to questions: a) Feeling of loneliness; b) Feeling of sadness; c) Difficulty sleeping due to worry; d) Number of close friends; e) Suicide ideation. Exposure variables were exposure to physical violence, involvement in fights and bullying. Logistic and linear regressions were used to verify the temporal trend of psychosocial stress, and to analyze the association between exposure of violence and psychosocial stress. RESULTS: Regardless of gender, the psychosocial stress score increasing trend between 2006 and 2016. The girls showed a variation in the feeling of loneliness from 18.7% to 22.8%, and suicide ideation increased from 10.4% to 14.2% between 2006 and 2016. All types of violence were associated with greater psychosocial stress for both boys and girls. CONCLUSION: Adolescents had a higher prevalence of feelings of loneliness, difficulty sleeping due to worry and suicide ideation during the period from 2006 to 2016, regardless of gender. Exposure to violence is associated with psychosocial stress in both genders, however, the strongest associations occurred in girls.

Depressive symptoms in older adults: the role of physical activity and social support.

OBJECTIVE: To evaluate the role of social support in the association between physical activity (PA) in its various domains and depressive symptoms in older adults. METHODS: This was a cross-sectional study involving 399 older adults seen at basic health units in the municipality of Recife, state of Pernambuco, northeastern Brazil. Linear regression was implemented using the forward method to assess the association between PA and its domains and depressive symptoms, as well as to test the possible moderating component of social support in this association. RESULTS: Of the total sample, 17.6% reported not practicing PA; 6.7% presented depressive symptoms, with a mean score of 1.59 points. A total of 18.6% of the older adults assessed reported not having social support. Older adults who did not practice total, transportation or domestic PA showed increased scores of depressive symptoms when compared to older adults who practiced PA in these domains. Older adults with social support also had fewer depressive symptoms. Practicing domestic, leisure and total PA, and/or having social support, decreased depressive symptoms in older adults. Having social support or practicing PA decreased depressive symptoms in older adults in a similar way. CONCLUSIONS: Older adults with social support and who practiced PA, especially domestic and total PA, presented the lowest scores of depressive symptoms. The data showed the importance of providing elements to strengthen social support and PA practice in older adults living in poor communities as a strategy to prevent and reduce depressive symptoms.

Prevalence of alcohol consumption and factors associated with binge drinking behavior among adolescents in the state of Pernambuco, Brazil, 2016

To investigate the prevalence of alcohol consumption and the factors associated with binge drinking behavior amongadolescents in the state of Pernambuco, Brazil. A cross-sectional study with a probabilistic sample of 6,002 adolescents composed of students from public high schools in Pernambuco, Brazil, aged 14 to 19 years. Binge drinking behavior was used as a dependent variable. The following were evaluated as possible risk factors: sociodemographic variables (gender, maternal education, marital status, work, religion); indicators of psychosocial stress (feelings of sadness; suicidal thoughts; feelings of loneliness;friends) and health risk behaviors (physical inactivity; number of sexual partners; drug use; and involvement in fights in the last year). Logistic regression was used to estimate odds ratios (OR). A total of 6,002 adolescents participated, with 75% reporting having consumed alcoholic beverages at least once in their lives. The prevalence of binge drinking in the last month was 17%. Adolescents without a religion had 81% (95%CI: 1.51; 2.16) more chance of consuming alcohol in excess. Adolescents who felt sad were 29% more likely to binge drink (95%CI: 1.08; 1.54), and adolescents who had already thought about suicide had 41% (95%CI: 1.13; 1.76) more chance to drink excessively. Adolescents who used illicit drugs had 4.6 times the chance (95%CI: 3.51; 6.17)of excessive drinking. Adolescents who engaged in four or more fights during the year were twice as likely to binge drink as those who did not fight (95%CI: 1.36; 2.88). The prevalence of alcohol consumption and binge drinking behavior was high. Sociodemographic factors, psychosocial stress and health risk behaviors were associated with binge drinking.

Risk and protective factors for mental disorders with onset in childhood/adolescence: An umbrella review of published meta-analyses of observational longitudinal studies.

The patho-etiology of mental disorders with onset in childhood or adolescence remains largely unknown. We conducted an umbrella review of meta-analyses (MAs) on environmental factors associated with mental disorders with onset in childhood/adolescence. We searched Pubmed-MEDLINE/EMBASE/PsycInfo databases, last search April 29th, 2020. Quality of MAs was measured with AMSTAR-2. Out of 6851 initial references, ten articles met inclusion criteria, providing 23 associations between 12 potential environmental factors and nine disorders (cases: 8884; N = 3,660,670). While almost half of the associations were nominally significant, none of them met criteria from either convincing or highly suggestive evidence. A single association was supported by suggestive evidence (maternal exposure to lithium or antipsychotics with neuromotor deficits), but it was affected by confounding by indication. Ten more associations had weak evidence, and 12 associations were not statistically significant. Quality of meta-analyses was rated as high in two, moderate in one, low in four, critically low in two, and not pertinent in one (individual participant data). Methodologically-sound research is needed in this field.

Consumo de álcool e drogas ilícitas e envolvimento de adolescentes em violência física em Pernambuco, Brasil / Alcohol and illicit drug consumption and involvement by adolescents in physical violence in Pernambuco, Brazil / Consumo de alcohol y drogas ilícitas e implicación de adolescentes en violencia física en Pernambuco, Brasil

O objetivo foi estimar a prevalência e analisar a associação do consumo de álcool e drogas ilícitas com indicadores de violência física em adolescentes. Estudo transversal repetido com estudantes do Ensino Médio em escolas da rede pública em Pernambuco, Brasil (2006, n = 4.207; 2011, n = 6.264). Os dados foram obtidos por questionário. Os indicadores de violência física foram: vitimização por violência física; envolvimento em brigas. As variáveis independentes foram: consumo de álcool e uso de drogas ilícitas. A regressão logística binária foi utilizada para verificar a associação entre o consumo de álcool e drogas e ter sofrido violência física. A prevalência do consumo de álcool por adolescentes que sofreram violência física reduziu em cinco anos, porém, nenhuma alteração foi constatada no uso de drogas ilícitas. As variáveis comportamentais estiveram associadas aos diferentes indicadores de violência, apresentando em geral uma tendência de aumento. Em 2006, adolescentes que usavam drogas ilícitas apresentaram uma chance 2,12 maior de sofrer violência física, e em 2011 este valor foi de 2,41 (IC95%: 1,80; 3,22). A chance de adolescentes que consumiam bebida alcoólica ter envolvimento em brigas aumentou de 1,96 (IC95%: 1,64; 2,34) em 2006, para 2,11 (IC95%: 1,78; 2,51) em 2011. O consumo de álcool pelos adolescentes que sofreram violência física diminuiu em cinco anos, entretanto, o risco de os adolescentes que consumiram bebida alcoólica ou usaram drogas ilícitas sofrerem violência física aumentou ao longo de cinco anos.

The article aimed to estimate prevalence and analyze the association between alcohol and illicit drug consumption and indicators of physical violence in adolescents. A repeated cross-sectional study was performed in public middle-school students in the State of Pernambuco, Brazil (2006, n = 4,207; 2011, n = 6,264). Data were obtained via a questionnaire. Indicators of physical violence were: victimization by physical violence and involvement in fights. The independent variables were alcohol and illicit drug consumption. Binary logistic regression was used to verify the association between alcohol and drug consumption and victimization from physical violence. Prevalence of alcohol consumption in adolescents that suffered physical violence decreased in five years, but no change appeared in the use of illicit drugs. The behavioral variables were associated with different indicators of violence, generally presenting an upward trend. In 2006, adolescents that used illicit drugs showed 2.12 higher odds of suffering physical violence, and in 2011 this value was 2.41 (95%CI: 1.80; 3.22). The odds of adolescents that consumed alcoholic beverages being involved in fights increased from 1.96 in 2006 (95%CI: 1.64; 2.34) to 2.11 in 2011 (95%CI: 1.78; 2.51). Alcohol consumption by adolescents that suffered physical violence decreased in five years, but the risk of adolescents that consumed alcohol or used illicit drugs and suffered physical violence increased over the course of five years.

El objetivo fue estimar la prevalencia y analizar la asociación del consumo de alcohol y drogas ilícitas con indicadores de violencia física en adolescentes. Se realizó un estudio transversal, repetido con estudiantes de enseñanza media en escuelas de la red pública en Pernambuco, Brasil (2006, n = 4.207; 2011, n = 6.264). Los datos se obtuvieron mediante cuestionario. Los indicadores de violencia física fueron: victimización por violencia física; implicación en peleas. Las variables independientes fueron consumo de alcohol y uso de drogas ilícitas. La regresión logística binaria fue utilizada para verificar la asociación entre consumo de alcohol y drogas y haber sufrido violencia física. La prevalencia del consumo de alcohol en adolescentes que sufrieron violencia física se redujo en cinco años, a pesar de que no se constató ninguna alteración en el uso de drogas ilícitas. Las variables comportamentales estuvieron asociadas a los diferentes indicadores de violencia, presentando en general una tendencia de aumento. En 2006, adolescentes que usaban drogas ilícitas presentaron una oportunidad 2,12 mayor de sufrir violencia física y en 2011 ese valor fue de 2,41 (IC95%: 1,80; 3,22). La oportunidad de adolescentes que consumían bebidas alcohólicas de que tuvieran implicación en peleas aumentó de 1,96 (IC95%: 1,64; 2,34) en 2006, a 2,11 (IC95% 1,78; 2,51) en 2011. El consumo de alcohol por parte de los adolescentes que sufrieron violencia física disminuyó en cinco años, no obstante, el riesgo de los adolescentes que consumieron bebidas alcohólica o consumieron drogas ilícitas sufrieran violencia física aumentó a lo largo de cinco años.

Constructs of poor sleep quality in adolescents: associated factors / Os construtos de baixa qualidade de sono em adolescentes: fatores associados / Constructos de calidad deficiente del sueño en adolescentes: factores asociados

This study aims to evaluate factors associated with sleep quality (overall and by domains) in adolescents. A cross-sectional study. This study was conducted with 1,296 first-year high school students from public schools in the Northern Region of the State of Pernambuco, Brazil. Demographic, socioeconomic, and behavioral data were obtained with a questionnaire. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI) Body mass index (BMI) was calculated based on the ratio of weight and height squared. Multilevel linear and logistic regressions evaluated factors associated with sleep quality. We observed 53% of adolescents reported poor sleep quality. Adolescents at higher risk of clinical depression were 3.45 times more likely to have poor sleep quality (95%CI: 2.04; 5.81), and each additional unit in the social anxiety score presented 1.03 (95%CI: 1.01; 1.05) higher odds of adolescents having poor sleep quality. Adolescents with depressive symptoms had higher sleep latency, greater sleep disturbance, and greater daytime sleep dysfunction. Social anxiety was associated with sleep latency, sleep disturbance, and daytime sleep dysfunction. Higher risk of clinical depression was associated with all domains related to sleep quality. Negative health perception was associated with sleep disturbance, and physical inactivity was associated with daytime sleep dysfunction. Social anxiety and especially higher risk of clinical depression were determinants of poor sleep quality. Changes in sleep latency, sleep disturbance and daytime sleep dysfunction seems to be relevant to poor sleep quality.

O estudo buscou avaliar os fatores associados à qualidade do sono (global e por domínios) entre adolescentes. Foi realizado um estudo transversal com 1.296 estudantes de primeiro ano do ensino médio em escolas públicas na Região Norte do Estado de Pernambuco, Brasil. Foram obtidos dados demográficos, socioeconômicos e comportamentais através de um questionário. A qualidade do sono foi medida com o Pittsburgh Sleep Quality Index (PSQI). O índice de massa corporal (IMC) foi calculado como peso dividido por altura ao quadrado. Os fatores associados à qualidade do sono foram avaliados através da regressão linear multinível e logística. Observamos que 53% dos adolescentes relatavam baixa qualidade de sono. Os adolescentes com risco maior de depressão clínica apresentaram 3,45 vezes maior probabilidade de apresentar baixa qualidade de sono (IC95%: 2,04; 5,81), e cada unidade adicional na escala de ansiedade social apresentou 1,03 vezes maiores chances (IC95%: 1,01; 1,05) de baixa qualidade de sono. Os adolescentes com sintomas depressivos mostraram maior latência do sono, maior transtorno do sono e maior disfunção diurna do sono. A ansiedade social mostrou associação com latência do sono, transtorno do sono e disfunção diurna do sono. O risco maior de depressão esteve associado a todos os domínios relacionados à qualidade. Autoavaliação de saúde negativa esteve associada ao transtorno do sono, e inatividade física esteve associada à disfunção diurna do sono. Ansiedade social, e principalmente risco maior de depressão clínica, foram determinantes na baixa qualidade do sono. Mudanças na latência do sono, transtorno do sono e disfunção diurna do sono parecem ser relevantes para a baixa qualidade do sono.

El objetivo de este estudio fue evaluar factores asociados con la calidad del sueño (general y por ámbitos) en adolescentes. Se realizó un estudio transversal con 1.296 estudiantes del primer año de escuela secundaria, procedentes de escuelas públicas en la Región Norte del Estado de Pernambuco, Brasil. Se obtuvieron datos demográficos, socioeconómicos y comportamentales, a través de un cuestionario. La calidad del sueño se midió usando el Pittsburgh Sleep Quality Index (PSQI). El índice de masa corporal (IMC) se calculó de la ratio de peso y altura al cuadrado. Las regresiones logísticas y lineales multinivel evaluaron factores asociados con calidad del sueño deficiente. Observamos que un 53% de los adolescentes informaron de una calidad de sueño deficiente. Los adolescentes con mayor riesgo de depresión clínica fueron 3,45 veces más propensos a tener una calidad de sueño deficiente (95%CI: 2,04; 5,81), y cada unidad adicional en la puntuación de ansiedad social presentaba 1,03 (95%CI: 1,01; 1,05) mayores posibilidades de adolescentes sufriendo por calidad de sueño deficiente. Los adolescentes con síntomas depresivos presentaban mayor latencia de sueño, mayores perturbaciones en el sueño, y mayor disfunción durante el día de sueño. La ansiedad social estuvo asociada con la latencia de sueño, perturbaciones de sueño y disfunción del sueño durante el día. Un mayor riesgo de depresión clínica estuvo asociado con todos los ámbitos relacionados con calidad del sueño. Una percepción negativa de salud respecto a la perturbación de sueño e inactividad física estuvo asociada con un sueño deficiente durante el día. La ansiedad social y, especialmente, un mayor riesgo de depresión clínica fueron determinantes en una escasa calidad de sueño. Los cambios en la latencia del sueño, trastornos del sueño y disfunción del sueño durante el día parecieron relevantes para la deficiente calidad del sueño.

Moving More and Sitting Less as Healthy Lifestyle Behaviors are Protective Factors for Insomnia, Depression, and Anxiety Among Adolescents During the COVID-19 Pandemic.

PURPOSE: This study aimed to investigate associations of physical activity time (PAT) and sitting time (ST) independently and jointly with insomnia, depressive and anxiety symptoms among Chinese adolescents in the context of COVID-19. METHODS: A cross-sectional study including 965 adolescents (mean age = 15.26, SD = 0.46) was conducted in May 2020. PAT, ST and the symptoms of insomnia, depression and anxiety were assessed with the International Physical Activity Questionnaire Short Form, the Youth Self-Rating Insomnia Scales, the 9-item Patient Health Questionnaire and the Generalized Anxiety Disorder scale via an online survey platform. Logistic regression was used to analyze the association between COVID-19-related fear, PAT, ST and combinations of PAT and ST with insomnia, depressive and anxiety symptoms. RESULTS: COVID-19-related fear was associated with higher odds of insomnia, depressive and anxiety symptoms. PAT was associated with lower odds of insomnia and depressive symptoms, while ST was associated with higher odds of these three symptoms. After combining PAT and ST, the group with both low PAT and high ST was set as the referent. For insomnia, groups with low ST reported significantly lower odds of symptoms. For depression, groups with high PAT and/or low ST reported lower odds of symptoms. Regarding anxiety, only the group with both high PAT and low ST reported lower odds of symptoms. Generally, group with both high PAT and low ST reported lower odds of the three symptoms than the referent. CONCLUSION: COVID-19-related fear was a risk factor for developing insomnia, depressive and anxiety symptoms among Chinese adolescents. Fortunately, moving more and sitting less were good for sleep and mental health in Chinese adolescents during the pandemic. Educators should help adolescents to be more physically active in their daily life in the primary prevention of adolescent insomnia, depression and anxiety.

Depression is Associated with Moderate-Intensity Physical Activity Among College Students During the COVID-19 Pandemic: Differs by Activity Level, Gender and Gender Role.

PURPOSE: The novel coronavirus disease (COVID-19) pandemic and associated restrictive measures have implications for depressive symptoms (henceforth depression) of young people and risk may be associated with their reduced physical activity (PA) level. Therefore, we aimed to examine the association between depressive symptoms and PA among college students with different gender and gender role (masculinity traits and femininity traits) during the COVID-19 pandemic. PARTICIPANTS AND METHODS: Cross-sectional study included 628 healthy college students from nineteen different locations. The Center for Epidemiological Studies Depression Scales (CES-D), the International Physical Activity Questionnaire - Short Form (IPAQ-SF), and the 50-item Chinese Sex-Role Inventory (CSRI-50) were used to measure depressive symptoms, PA continuous (weekly metabolic equivalent minutes, MET-minutes/week) and categorical indicators (activity level category) and gender role, respectively. The statistical analyses were used in partial correlation analysis, t-test, one-way ANOVA, moderation model tests, and linear regression model tests. RESULTS: Total of 34.72% participants had clinically relevant depression (16, CES-D scale). Total of 58.6% participants were classified as a "low" activity level for spending less time on PA. Depression significantly negatively correlated with MET-minutes/week in moderate-intensity PA but not vigorous and walking scores. Of note, the depression-PA association was only moderated by the "low" activity level group in terms of categorical scores across gender groups. Participants with higher masculinity traits were less likely to have depression among all participants. Moreover, more recovered cases and fewer deaths could also predict the lower depression risk in the "high" activity level group. CONCLUSION: Moderate-intensity PA is beneficial for reducing depression risk among college students at a low activity level. College students with fewer masculinity traits (regardless of gender) are highly vulnerable to depression during the outbreak of COVID-19. Effective control of the COVID-19 pandemic seems critical to alleviating the burden of mental disorders of the public including depression.